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Qu J, Liu Q, You G, Ye L, Jin Y, Kong L, Guo W, Xu Q, Sun Y

This is a self protective mechanism against TNF- induced oxidative stress

doi: 10.1007/s11239-012-0759-x

By contrast, despite promoting increased ROS production, human cytomegalovirus (HCMV) infection positively modulates Nrf2 expression

This emanates from the fact that synthetic drugs are designed for just a purpose (for instance, treatment of a particular disease) and targeting a certain pathway and mechanism, while a large number of studies have revealed that naturally-occuring compounds are capable of affecting a wide variety of molecular signaling pathways (Guo et al., 2019