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UV exposure induced upregulation of p16INK4a, p21CIP1, and p53 in fibroblasts, presenting a senescence phenotype (78)

Dihexa targets synaptic remodeling through HGF/c-Met signaling, a fundamentally different mechanism, but it has never been tested in human clinical trials and lacks the safety data, dosing guidelines, and efficacy proof required for FDA approval

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(2007) Anthropometric risk factors for patellar tendon injury among volleyball players