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The panelists agreed that symptoms related to the peripheral and central nervous systems are the most common symptoms in patients with clinically manifested vitamin B12 deficiency (Figure S3)

In cases where a chronic condition is causing a deficiency, people may require B12 shots around every 2 months

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The most common adverse reactions (incidence 20%) of pemetrexed, when administered in combination with cisplatin are vomiting, neutropenia, anemia, stomatitis/pharyngitis, thrombocytopenia, and constipation