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Description

The hepatokines belong to organokines, which are functional proteins exclusively or predominantly produced by and secreted from a specific tissue or organ, for example, fibroblast growth factor 21 (FGF-21) can secrete from the liver, adipose tissues, and skeletal muscle, and thus, it acts as a hepatokine, adipokine, and myokine, respectively

2013;8:e79837

The liver, in particular, is responsible for processing excess substances in the bloodstream

In mice, increasing oxidative damage decreases life span, though in Caenorhabditis, blocking production of superoxide dismutase actually increases lifespan, so the role of ROS in aging is not completely clear