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Evidence of tumors, specifically osteosarcoma, has been discovered in human fossils from South Africa, showcasing the ancient existence of this disease [1]

3 , 4 Regardless of whether it occurs as a result of a single overdose or after repeated supratherapeutic ingestion, the progression of acetaminophen poisoning can be categorized into four stages: preclinical toxic effects (a normal serum alanine aminotransferase concentration), hepatic injury (an elevated alanine aminotransferase concentration), hepatic failure (hepatic injury with hepatic encephalopathy 5 ), and recovery

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Mellott TJ, Kowall NW, Lopez-Couiella I, Blusztajn JK: Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats