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J ) Proportion of ductal structures bigger or smaller than 100 m of Aldh1l2 WT acinar cells after 4 days of culture with or without 300M NAC

Pathologies of the haemolymphopoietic system Thrombocytopenia, leukopenia, anemia, agranulocytosis Immune system disorders Hypersensitivity reactions (urticaria, laryngeal edema, angioedema, anaphylactic shock) Nervous system disorders Dizziness Gastrointestinal disorders Gastrointestinal reaction Hepatobiliary pathologies Abnormal liver function, hepatitis Skin and subcutaneous tissue disorders Erythema multiforme, Stevens Johnson syndrome, Epidermal necrolysis, Skin rash Kidney and urinary disorders Acute renal failure, interstitial nephritis, hematuria, anuria

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The thermal cycling comprised an initial denaturation step at 95 C for 4 min, followed by 35 cycles at 95 C for 30 s, 59 C for 30 s and 72 C for 30 s, with the final extension at 72 C for 7 min