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When System XC - was inhibited by compounds such as Erastin and sorafenib, GSH synthesis was reduced, leading to the failure of GPx4 to reduce lipid peroxides using GSH, thus leading to ferroptosis [10]

The nutrient deficiency can also activate the NOD-like receptor (NLR) family and pyrin domain-containing 3 (NLRP3) inflammasome and induce IL-1 secretion in high fat diet-induced atherosclerosis animal model 48 , whereas zinc supplementation can inhibit NLRP3 inflammasome activation through its antioxidant effects in an in vitro study 49

10.1016/j.bbapap.2015.01.014 Biochim

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