Abbreviations DUBs: Deubiquitinases GPX4: Glutathione peroxidase SLC7A11: Solute Carrier Family 7 Member 11 PROTACs: Proteolysis TArgeting Chimeras Ub: Ubiquitin FBXW7: F-box and WD repeat-domain containing 7 SOX9: SRY-box transcription factor 9 SOCS2: Suppressor of Cytokine Signaling 2 TRIM21: Tripartite Motif Containing 21 VDAC2: Voltage-dependent anion channel 2 SMURF2: Smad ubiquitination regulatory factor 2 cGAS: Cyclic GMP-AMP Synthase STING: Stimulator of Interferon Genes USP14: Ubiquitin specific peptidase 14 ALKBH5: AlkB homolog 5 NHEJ: Non-homologous end joining TRAF4: TNF receptor-associated factor 4 MCL-1: Myeloid cell leukemia-1 UBE2T: Ubiquitin-conjugating enzyme E2T FANCD2: FA group D2 protein H2Bub1: Monoubiquitylation of histone H2B SUPT16H: Suppressor of Ty homolog-16 EMT: Epithelial-mesenchymal transition OTUD5: OTU deubiquitinase 5 EZH2: Enhancer of zeste homolog 2 TNBC: Triple negative breast cancer KAP1: KRAB domain-associated protein 1 MDM2: Murine double minute 2 KLF5: Krppel-like factor 5 SENP: Sentrin-specific protease RUVBL1: RuvB-like protein 1 DTL: Dentideless IGF2BP2: Insulin-like growth factor 2 mRNA-binding protein 2 PTM: Post-translational modification NSCLC: Non-small cell lung cancer ESR1: Estrogen receptor CTH: Cystathionase CRLs: Cullin-RING complexes PDOs: Patient-derived organoids HRR: Homologous recombination repair NCTD: Norcantharidin HNSCC: Head and neck squamous cell carcinoma References Huang RX, Zhou PK
A host of studies have highlighted the importance of AMPK inactivation in the pathogenesis of diabetic cardiomyopathy ( 2 S might protect cardiomyocytes from hyperglycemia stress through AMPK-mediated inhibition of mTOR
Multifunctional liposomes, for instance, have been used to co-deliver antibiotics and natural photosensitizers
Inorganic mercury may also enter water or soil from the weathering of rocks that contain mercury, from factories or water treatment facilities that release water contaminated with mercury, and from incineration of municipal garbage that contains mercury (for example, in thermometers, electrical switches, or batteries that have been thrown away)
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