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In specific embodiments, Ab is an anti-FRa antibodies which comprises the 6 CDRs which are 100% identical to corresponding CDRs of SEQ ID NO: 1-6, and the framework amino acid regions which are at least 90%, 91 %, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% identical to the corresponding framework amino acid regions as specified in SEQ ID NO: 7 and 8 respectively, wherein said anti-FRa antibody has the following properties: (i) it binds to the folate receptor receptor a (FRa) as determined by Elisa assay (as described in the Examples) with an EC50 below 5nM, for example about 0.5nM

Abrupt jumps skip the tolerability buffer and are the most common cause of severe nausea

doi: 10.1016/j.jconrel.2022.03.046 110 OngunMLokrasAGBaghelSShiZSchmidtSTFranzykHet al

wild-type (WT) was considered statistically significant

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