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doi: 10.1016/S0891-5849(03)00062-5, 50

Science (1975) 190(4212):3979

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The spirosuccinimide of ( S )-dHTC1 engages the IMiD-binding site of CRBN but, interestingly, it adopts a slightly different pose in the ternary complex compared to what was revealed by the cocrystal structure of the binary complex (Extended Data Fig