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The results showed that treatment with Tesofensine led to significant weight reduction compared to the placebo group

As patient susceptibility is probably related to individual differences in genetic and metabolic landscape, the upcoming challenge could be to take advantage of the highly improved genomic, proteomic, and metabolomic approaches to identify possible targets useful for personalized treatments

Lescure A, Gautheret D, Carbon P, Krol A

This study highlighted the physiological importance of altering the signaling strength of these pathways as exon 3-deleted GHR individuals were found to be of higher stature with extended lifespan (113)