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These observations underscore an important therapeutic implication for MASLD, showing that the timing and disease stage may be critical for maximizing the protective effects of GSH depletion, with the greatest benefit likely occurring during early, lipogenesis-driven phases of MASLD progression

In recent years, an increasing number of clinical and basic studies have emphasized the significant role of transporters in the occurrence of HDIs

One unit of SOD was defined as the amount of enzyme needed to exhibit 50% dismutation of the superoxide radical

It releases constituent metal ions into the aqueous phase, creating a mixed exposure scenario.85 The dissolution rate (dC/dt) is governed by the NoyesWhitney framework but is critically modulated by environmental factors.86 Kinetic data show that dissolution half-lives (t1/2) vary by orders of magnitude: ZnO nanoparticles may exhibit a t1/2 of mere hours in acidic waters (pH 5) versus weeks in neutral, NOM-rich waters where surface passivation occurs.87,88 This pathway is the mechanistic basis of the Trojan Horse hypothesis.7173,75 Surface transformations and the eco-corona: defining the bio-nano interface The surface of an ENM is its active interface with the environment