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Unlike vaccine-induced antibodies, monoclonal antibodies can be engineered with molecular precision

Diabetologia 65 , 457466 (2022)

At the same time, D-loop aspartic acid (protonated) donates a proton to the oxygen atom of the substrate, facilitating the removal of the phosphate group and the release of the dephosphorylated substrate

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NICE and British Society for Haematology guidelines recommend: Initial treatment with hydroxocobalamin (the preferred form in the UK) via intramuscular injection For patients without neurological involvement: 1 mg IM three times a week for 2 weeks For patients with neurological involvement: 1 mg IM on alternate days until no further improvement Maintenance: 1 mg every 3 months for patients without neurological involvement