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Post-mortem analysis of the prefrontal cortex showed significantly increased levels of 8-OH-Gua (see also above) which may in turn affect the aggregation of proteins (Balmus et al

The CpG island methylation phenotype (CIMP) is defined as the high activity of global and nonrandom CpG island methylation

Key mechanisms include gut barrier dysfunction, short-chain fatty acid (SCFA) depletion, lipopolysaccharides (LPS)-induced inflammation, and ferroptosis-mediated atrial remodeling