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Description

It is reported that in ATC, lactate accumulation promotes globally protein lactylation, especially the histone lysine lactylation, activating the expression of multiple essential genes involved in ATC including CTGF, CCNE1, CDK1, KLF2, IL1B, and AURKB [85]

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We are confident that in the next 30 years, the therapeutic landscape for SCD will change due to a combination of recent advancements in genetics and genomics, an increase in the number of competing clinical trials, and also an increased awareness from the funding bodies, in particular the NIH, USA