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scRNA-seq and ST analysis revealed a predominant intrahepatic immune cell cluster expressing CD11b and CSF1 surrounding proliferative cholangiocytes in Reg1 KO mice but not in WT mice

The recent discovery of pharmacological ABHD5 ligands that disrupt the interaction between ABHD5 and PLIN1 (48) demonstrate that the dissociation of ABHD5 is sufficient to stimulate adipocyte lipolysis and that these protein interactions can be targeted pharmacologically (34, 48, 49)