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Bacterial Biofilm in Chronic Wounds and Possible Therapeutic Approaches

KRAS is an oncogenic protein that is commonly activated in many tumors, including lung cancer and pancreatic cancer, and it has been considered an undruggable target because it lacks a classical drug binding site 143,144

The histidine residue serves as the primary copper-binding site, while the lysine residue contributes to cellular uptake through electrostatic interactions with negatively charged cell membranes

Samples for analysis were fractionated via Pierce High pH Reversed-Phase Peptide Fractionation kit (Thermo Fisher Scientific) according to Manufacturers instructions

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