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doi: 10.3390/app10103353 Summary Keywords PCOS, flavonoids, apigenin, ellagic acid, natural bio-actives, pharmacokinetics Citation Balkrishna A, Rana M, Mishra S, Agrawal R, Rajput SK, Dhanasekaran M, Rana M, Arya V, Ramu R, Upadhayay A and Singh S (2025) Exploring the therapeutic potential of phytochemicals apigenin and ellagic acid in managing polycystic ovarian syndrome and its comorbidities: a comprehensive review

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Increased permeability supports nanoparticle extravasation in selected regions, while poor perfusion, high interstitial pressure and heterogeneous flow limit uniform delivery across the tumor mass [17, 33]