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Proliferation (log 2 doublings, 5 days) of indicated GPX4-deficient cell lines in vitro left untreated or supplemented with -toc, vitamin D3, or 7-DHC at indicated concentrations

Free radicals play critical role in generating oxidative stress, which oxidizes dopamine to dopamine quinone and superoxide anion and decreases the NADPH and dopamine metabolized by MOA that produces the 3,4-dihydroxyphenylacetaldehyde, ammonia, and H 2 O 2 , which in turn interacts with Fe ++ to generates the OH free radicals that kill neurons in PD [61, 62]

This is hugely important for our health as it plays a crucial role in the bodys defenses, in metabolising nutrients and in regulating various pathways essential for general equilibrium

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Besides this, a functionally active construct (dDAT mfc ) (Supplementary Fig