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MARCH was a 26-week, randomized, placebo-controlled (PBO), Phase 3 trial of maralixibat (MRX), an ileal bile acid transporter (IBAT) inhibitor, that achieved its primary and key secondary endpoints of pruritus and sBA reduction for individuals across the broadest range of PFIC types studied

Drug design, development and therapy , 16 , 19631974.

Once positioned in the MRI scanner, they performed the Rule Switching task during the fMRI acquisition session (~6 min)

The aim of surgery for IVD disease is to relieve the compression of neural structures, and procedures include removal of the NP (nucleotomy) through fenestration of the AF alone or combined with partial removal of the vertebral roof (laminectomy) or vertebral body (ventral decompression) [12]

Energy Status Dictates PD-L1 Protein Abundance and Anti-Tumor Immunity to Enable Checkpoint Blockade