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This ionization increased with an increase of pH value

The researchers also discovered that occluding the treatment, by sealing it with a parafilm or saran wrap dressing for constant contact increased drug delivery up to 10-fold (17)

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Other than interfering with drug uptake, HIF-1 increases chemoresistance through inducing the anti-apoptotic protein Bcl-2, and inhibiting the pro-apoptotic protein Bax [68,69]