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Ascorbic acid can also directly enhance the catalytic activity of Tet methylcytosine dioxygenase 2 (TET2) in the oxidation of 5-methylcytosine (5mC), promote the folding and/or recycling of the cofactor Fe (2 + ) for TET2, and improve symptoms of depression (Ma et al., 2024

Identification of gene cluster based on prognostic DEGs and construction of SAAM score To comprehensively understand the molecular characteristics of various SAAM patterns, the consensus clustering analysis was executed, and the STAD patients were identified into three gene clusters (1, 2, and 3) based on 284 prognostic DEGs screened out from the DEGs of three SAAM clusters (Figure S5)