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Aside from cytosolic amino acid sensors, intra-lysosomal amino acid sensing coincided with the identification of SLC38A9, a lysosomal transmembrane protein likely belonging to arginine transporters and an integral part of mTORC1 activation via Ragulator-RAG GTPases (Jung et al., 2015

Oxidative stress, as reflected by glutathione status, appeared to be an earlier signal than inflammation in the trajectory of age-related cognitive decline

They also reported that baseline upregulation of HIF-1 and peroxisome proliferator-activated receptor- (PPAR) in these cells may contribute to the transcriptional activation of PDK4

Cancer Lett (2010) 290(2):14856

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