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The experimental data is listed in table 11.Table 11 The example data of preparation of L-carnitine from L-3-cyano-2-hydroxypropyl trimethylammonium having different optical purity Example 1 Establish the detecting method of the optical purity of epichlorohydrin with gas chromatography Example 2 Detection of the content of the D-isomer of the intermediate (L-3-cyano -2 - hydroxypropyl trimethyl ammonium) Example 3 Preparation of L-carnitine started from S-epichlorohydrin having different optical purity Example 4 Preparation of L-carnitine from L-3-chloro-2-hydroxypropyl trimethylammonium Example 5 Preparation of L-carnitine from L-3-cyano-2-hydroxypropyl trimethylammonium Claims (8) A Preparation Method of high-Purity L-carnitine, characterized in that to prepare L-carnitine with a purity being above 97%, wherein the content of D-carnitine is below 2%, by detecting and controlling the content of chiral material and chiral intermediate during the whole synthetic process which is started from S-epichlorohydrin, wherein the method include the following steps:(1)Detect the content of optical isomers of S-epichlorohydrin with GC and chiral column, and control the content of laevoisomer of S-epichlorohydrin within the range of 0% -12% W/W;(2)Detect the specific rotation of the intermediate L-3-chloro-2-hydroxypropyl trimethylamine during the synthetic process with a polarimeter, and control the value within the range of -26.0 -29.4;(3)Detect the optical purity of L-3-cyan-2-hydroxypropyl trimethylamine of the intermediate mixture and the content of its dextroisomer with a chiral derivatization reagent, and control the content of the dextroisomer within the range of 03.6%W/W;wherein the said chiral derivatization reagent is the optically pure D- or L-compound of formula (II):wherein, the carbon atom marked with an asterisk is the chiral carbon atom
La L-Carnitine possde aussi des effets nergisants car elle contribue transformer les graisses en source d'nergie
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1992;267:12673-81 56 -Arduini A ea
