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Lin, P., Liu, L., Ma, Y., Du, R., Yi, C., Li, P., Xu, Y., Yin, H., Sun, L., & Li, Z.-H

The accepted mechanism of this catalytic reaction (derived from many years of biochemical and modelling studies) envisages a two-step process shown in Equations 2 and 3 [Alfonso-Prieto, 2008]

doi: 10.1186/s13048-020-00758-w 19 HeLZhuWChenQYuanYWangYWangJet al

In this case, KAR 1 might need to be converted into an active form in vivo for signal transduction to occur (Supplementary Fig