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Hence, it can be seen that many environmental pollutants are capable of inducing eryptosis in human RBCs, and that eryptosis may be an effective indicator for comparing the hematotoxicity of parent compounds and their metabolites [423], to assess the toxicity of their potential replacements [421, 422, 428], and to investigate the mechanisms of action of toxic metals [184, 420, 424, 435] and pesticides [436, 437]

doi: 10.1016/j.chemosphere.2023.141100 279 ZhangC.WangX.ZhangX

ISMP Medication Safety Alert!, 23(24), 1-4

Beyond these direct effects on redox status, Nrf2 also modulates the expression of genes implicated in cellular defense, thereby inhibiting redox cycle reactions and diminishing GSH consumption (52)

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