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In addition, the hinokitiol copper complex (CuHK) has been confirmed as an inhibitor of the 19S DUB, but not the CT-like activity of the 20S proteasome ( Conclusion and Perspectives The essential role of the UPS in controlling cancer biology has aroused great interest in the development of proteasome inhibitors as anticancer drugs

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This process is driven by the failure of cellular antioxidant defenses, particularly the GPX4 system, which neutralizes typically lipid peroxides using glutathione (GSH) [86, 87]