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These technological advances may help improve our understanding of metabolic signatures in respiratory diseases and establish a robust foundation for developing more precise diagnostic and therapeutic strategies

This analysis revealed that SAM-modulating methyltransferases such as GNMT, PEMT, NNMT and COMT clustered with other highly tissue-specific methyltransferases ( Figure 1B )

SUPPLEMENTAL INFORMATION Supplemental information can be found online at STAR METHODS KEY RESOURCES TABLE EXPERIMENTAL MODEL AND STUDY PARTICIPANT DETAILS Mouse strains Protocols for all rodent experiments were approved by the Institutional Animal Care and the Animal Committee of Xiamen University (XMULAC20180028 and XMULAC20220050)