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Across diverse cell sources (dental pulp, mesenchyme, olfactory mucosa, induced pluripotent cells, Tregs and even homeostatic M2 microglia) the common therapeutic denominator is delivery of RNA cargo that throttles one of three pressure points in the pyroptotic cascade: (i) inflammasome activation (NLRP3 or AIM2), (ii) execution (GSDMD) or (iii) transcriptional priming (NF-B/NKAP)

Boutell JM, Wood JD, Harper PS, Jones AL

Consequently, it was hypothesized that electrostatic interactions play a significant role in the interactions between these two domains

Thus, we found no differences in PBMC cytokine production capacity after MMR vaccination

Chrysis D, Calikoglu AS, Ye P, DErcole AJ: Insulin-like growth factor-I overexpression attenuates cerebellar apoptosis by altering the expression of Bcl family proteins in a developmentally specific manner