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Low B12 causes raised Homocysteine

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2020;232 doi: 10.1016/j.biomaterials.2019.119736

Enhanced Serotonin Synthesis Pathway: Tryptophan (requires folate + B12 for methylation) 5-Hydroxytryptophan (5-HTP) Serotonin B12s Role: Supports enzymatic conversion Provides methyl groups via SAMe Optimizes tryptophan hydroxylase activity Clinical Effect: More serotonin is available for SSRIs to work with Enhanced synaptic serotonin levels Better antidepressant response 2

Vitamin B12 deficiency treatment is often recommended if you experience fatigue, weakness, or nerve-related symptoms