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In hematopoietic stem cells (HSC), histone deubiquitinase MYSM1 was shown to mediate the vulnerabilities of HSC to ferroptosis stress by regulating protein synthesis

For example, MDC1, an essential protein that triggers the DNA damage response, can be ubiquitinated and subsequent degraded by RNF4, which can be reversed by deubiquitinating enzyme ATX3 [116]

All necessary amino acids are present in mushrooms high in protein, and glutamic acid, aspartic acid, and arginine are three of these abundant amino acids (Farhan and Chechan 2023)

10.1023/b:ddas.0000004520.71462.c9 Dig

Unlike other vitamins, B12 is primarily found in animal-based foods, such as meat, fish, eggs, and dairy products, and can be difficult to obtain from plant-based diets