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It was further demonstrated that deletion of one Alox12 allele in mouse promotes lymphomagenesis in E-Myc models, and that ALOX12 missense mutations derived from human cancers lose their capabilities to oxygenate PUFA and to promote p53-mediated ferroptosis (Chu et al., 2019)

Healthy homocysteine metabolism is important for cardiovascular health

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This work was supported by National Institutes of Health (NIH) R01CA183989 and R01GM132142 to M.K., Chao Family Comprehensive Cancer Center Pilot Award, Cancer Center Support Grant P30-CA062203 (to University of California, Irvine), and the American Cancer Society Research Scholar (RSG-16-085-01-TBE)