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10.1371/journal.pone.0024840 63 PaceT

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Concurrently, SCFAs enhance intestinal barrier integrity by upregulating tight junction proteins (e.g., occludin), which reduces systemic lipopolysaccharide (LPS) leakage and inhibits TLR4/NF-B-driven synovial inflammation (24, 25)

To evaluate whether LOsG induces ROS homeostasis disorder, a timely intraperitoneal injection of GSH (50 mg/kg/6 h) was made into animals challenged with LOsG as described above (LOsG.TdGSH group, n = 10)