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These facts are consistent with the findings of the present study, as there was a massive increase in MDA and iNOS oxidative biomarkers along with an abnormal decrease in GSH and TAC in pulmonary tissues of PQ-injected rats, while ARNI-treated groups showed a decrease in both MDA and iNOS with a considerable increase in GSH and TAC indicating a possible antioxidant effect of ARNI which was confirmed in a study of myocardial injury in rats by Refaie et al

Holler, T

For deeper mechanistic insights, we employed proteomic profiling and mitochondrial functional assays