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By contrast, the labile conjugate, which rapidly degrades to release estradiol, did result in increased uterine weight, suggesting off-target effects

Treatment with AOHP improved the innate immune status of the mice, and no obvious toxicity was observed

E.Rhule-SmithA.et al (2009)

The main difference between the two types of NETosis is that suicidal NETosis implies cell death of neutrophils, whereas vital NETosis preserves living neutrophil functions (e.g., phagocytosis and chemotaxis) (47, 48)