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In prepubertal female rats, a cerebroventricular infusion of IGF1 stimulated the secretion of GnRH and might advance the onset of puberty [15, 18]

Some metabolic modulators, such as metformin [308] and statins [309], have been used to exert additional cancer-treatment effects

Other studies in GERD patients reported that the reflex of gastric acid contents into the airways, in the presence of impaired esophageal peristalsis, may lead to local irritation and respiratory symptoms [31]

ButlerTLiYTsuiWFriedmanDMaozAWangXet al

It can be concluded from the above findings that acetaminophen-induced hepatotoxicity can be a possible cause of MAPK downstream JNK pathway activation