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Elevated GGT expression is generally associated with poor prognosis, as patients with high levels of GGT in tumors exhibit shorter overall and progression-free survival (60)

doi: 10.1016/j.jpba.2020.113293 46 GaoM.MonianP.PanQ.ZhangW.XiangJ.JiangX

IMO-2125, also known as Tilsotolimod, a synthetic phosphorothioate oligodeoxyribonucleotides, has shown a good safety profile with effective activation of dendritic cells, induction of type I IFN signaling, and up-regulation of multiple immune checkpoint pathways in a phase I trial (NCT03052205) (213), where IMO-2125 was usedas a monotherapy administrated intratumorally in refractory solid tumors

doi:10.3390/ijms21113858