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The lid domain and glycine-rich loop are critical for ATP binding, which triggers major shifts in their conformations (Galant et al., 2009)

The debated toxic role of aggregated TDP-43 in amyotrophic lateral sclerosis: a resolution in sight

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In addition, the color of the edges indicates changes concerning the respective reference group, where darker red hues indicate an increase in neighborhood occupation of the cluster, and blue values indicate a decrease