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doi: 10.1016/j.antiviral.2018.11.007

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This dysfunction is associated with disrupted cytokine signaling (e.g., TGF-), enhanced oxidative stress, and abnormal fibroblast activity, ultimately leading to disordered ECM deposition and tissue fibrosis ( Moreover, hyperglycemia stimulates pro-inflammatory cytokines (e.g., TNF-, IL-1), growth factors (e.g., PDGF, TGF-), and accumulation of AGEs, all of which dysregulate collagen and elastin synthesis