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There is no completed human efficacy trial

Although neem has been extensively investigated in the non-clinical setting, only a handful of clinical studies have been published, of which none were conducted in pregnant women (Pai et al., 2004)

Metallothionein-I/II expression associates with the astrocyte DNA damage response and not Alzheimer-type pathology in the aging brain

Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression

The studies included all took place in China, so some degree of cultural bias cannot be ruled out