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doi: 10.1016/j.jenvman.2023.118021

435,436 Neuronal injury promotes a neuroinflammatory response, leading to the accumulation of immune cells and the release of inflammatory cytokines, contributing to neuronal hypersensitivity

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Ongoing research examines how it interacts with neural signaling and mechanisms linked to brain plasticity

Because it stimulates the upstream signaling step (rather than supplying GH directly), sermorelin is commonly described as helping preserve the GH axiss built-in feedback controls including inhibitory tone from somatostatin and downstream regulation via IGF-1 which may reduce the likelihood of sustained, non-physiologic hormone elevations in research models