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It disrupts the copper chaperone system (e.g., COX17, SCO1/SCO2), drastically reducing CCO biosynthesis and activity

Unlike oral supplements, where absorption can be limited to about 50% or less, IV therapy bypasses the gastrointestinal tract to deliver micronutrients directly into the bloodstream

a-c Mean values in the same column with different lowercase letters indicate significant difference (P 0.05)

In the United States alone, the annual direct medical costs associated with RA are estimated to exceed $19 billion, with indirect costs such as lost productivity further amplifying the economic impact 5