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Increased glycosaminoglycan synthesis : Reviewed in Pickart & Margolina 2018, supporting structural hydration capacity

Homologous Recombination Deficiency (HRD) plays a critical role in HGSOC drug resistance, rendering tumor cells more sensitive to DNA-damaging agents such as platinum compounds and PARP inhibitors

F 2 -isoprostanes Isoprostanes are specific prostaglandin-like molecules formed by the non-enzymatic ROS-mediated peroxidation of PUFAs, involving for example arachidonic acid (Milne et al

Around 20-40% of white or Hispanic people carry this mutation, which reduces enzyme function by 35%

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