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doi: 10.1007/s10495-014-0990-3 63 LiYWangZChenYPetersenRBZhengLHuangK

Restylane is a safe and natural cosmetic dermal filler that can be used to fill more superficial wrinkles and folds (such as those around the mouth and below the eyes)

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This triggers protein kinase A (PKA) activation, which phosphorylates the transcription factor CREB and upregulates GH messenger RNA transcription

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