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Stimulated by gentamicin and other poisons, TLR4 on KCs surface is activated, and TNF-, IL-6 and other pro-inflammatory factors are secreted through MyD88-dependent pathway (Yang et al., 2022

16 Bojrquez-QuintalE.Escalante-MagaaC.Echevarra-MachadoI.Martnez-EstvezM

By modulating neurotransmitter levels, reducing neuroinflammation (40), and enhancing cognitive function through oxidative stress protection and increased hippocampal synaptic plasticity (36), it exerts protective effects against AD, as evidenced in preclinical studies