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A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, 101 thereby being roughly four times higher than those in normal rats

Primeau V, Coderre L, Karelis AD, Brochu M, Lavoie M-E, Messier V, et al

Chen Sci Rep 2025;15:18063

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Collagen and elastin stimulation Fibroblasts produce collagen and elastin, the structural proteins that keep skin firm and resilient