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2.3.3 Ferroptosis and apoptosis Apoptosis is a common mechanism of programmed cell death, which can be initiated by external or internal pathways

The accumulation of these PL-PUFA-OOH molecules disrupts the integrity and fluidity of the cell membrane, ultimately leading to membrane rupture, the release of the cellular contents and cell death (18)

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2.3 Cadmium toxicity and its detrimental impact on human health Cadmium-induced itai-itai disease causes a variety of symptoms, including reduced bone mineralization, a high incidence of injuries, an elevated risk of osteoarthritis, and severe bone discomfort

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