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To assess whether hypoxia promoted mitophagy in the model of glaucoma used here and 4 weeks after OHT, we evaluated the BNIP3-NIX pathway of receptor-mediated mitophagy

Increased expression of Hsp70 causes the downregulation of dynamin, which transfers the death receptor Fas to the cell surface, inducing apoptosis, and thus Hsp70 acts neuroprotectively (Glke et al., 2018)

Furthermore, in spite of considerable research efforts (Dixon et al., We propose a model describing the diverse roles of plant GSTs in the interactions of plant hosts with pathogenic microbes considering four different plant-pathogen interaction types (Table 1): (1) symptomless resistance (including basal resistance to bacteria and symptomless R gene-mediated resistance to viruses), (2) HR-associated resistance, (3) limiting susceptibility to systemic spread of pathogens and plant cell/tissue death (during infections by hemibiotrophic/necrotrophic fungi, bacteria, and viruses), (4) promoting susceptibility to biotrophic fungi and viruses (maintaining reduced conditions in infected non-necrotic plant tissues)

Both extracellular Hb and heme are implicated in macrophage polarization triggering the formation of hemorrhage-associated M(Hb) and M(heme) subsets, respectively (103106)

Bioinformatic analysis suggested that the L-proline biosynthetic pathway may have a second role in -glutamyl cysteine formation in prokaryotes