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Moreover, MDM2 inhibitors like Nutlin-3 and its derivatives (Idasanutlin/RG7388) have commenced clinical studies for solid tumors and hematological malignancies

Trujillo-Vargas et al., 2020)

This dual role, stimulating both synthesis and controlled degradation, is characteristic of wound healing rather than simple collagen accumulation

Abstract Bladder cancer remains a significant global health concern, with environmental carcinogen exposureparticularly from tobacco-derived compounds such as aromatic amines, polycyclic aromatic hydrocarbons (PAHs), and nitrosaminesrecognized as a primary etiological factor