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Given that diverse extracellular cues can provoke neutrophils to form NETs, our findings suggest that ROS and Ca 2+ act as two principal intracellular mediators of this process

(2020), in which 1.0 ml of the reaction mixture contained 50 mmol/L potassium phosphate buffer (pH 7.5), supernatant, 1 mmol/L GSSG, 0.75 mmol/L [5,5-dithiobis-(2-nitrobenzoic acid)], and 0.1 mmol/L NADPH

However, the direct oxidation of Cys and, to a lesser extent, methionine residues with H 2 O 2 can give rise to reversible modifications, such as sulfenic acid or disulfides or as methionine sulfoxides, respectively, which can be reduced by cellular activities

10.1038/s41598-022-11516-x Sci Rep 88 GeoffroyP